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Clinical reviews note that ZnC has a long history of use without major reported side effects

Urine klotho is lower in critically ill patients with versus without acute kidney injury and associates with major adverse kidney events

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Thus, CHAC1s role in inducing ER stress and ferroptosis highlights its potential as a therapeutic target to increase the efficacy of DTX in treating castration-resistant prostate cancer ( In vivo experiments confirmed that knocking down miR-432-5p in CAFs enhanced CHAC1 expression, increased ferroptosis, and improved the efficacy of docetaxel in reducing tumor growth

doi: 10.1016/j.psj.2024.103482 72 WangSZhangBChangXZhaoHZhangHZhaoTet al